AP0844 High Sensitive Biosensor for in vitro Detection of Patulin Based on Optical Planar Waveguide

Abstract

Mycotoxins present a concern to human health due to its adverse human health effects which ranged from poisoning to cancer and immune deficiency. Therefore, accurate and sensitive quantitative detection methods are of primary importance to limit their risk.  This work aims to provide a high sensitive biosensor for the in vitro detection of mycotoxin (in particular Patulin) using optical planar waveguide and highly specific bio receptor. In this system,  a polarization controlled laser traveling through the waveguide core and the sensor working as a polarization state detection, via observe the phase shift between s- and p-components of propagation light which caused by the molecular adsorption at the core-cladding interface. The refractive index sensitivity of this experimental setup has reached~9600RIU/rad, which is considered one of the highest values have demonstrated. This sensitivity value enabled this system to detect mycotoxin molecules in extreme low concentrations in range of 0.01 ng/mL.