Radioprotective Potential of Cinnamon Nanoparticles Against Gamma Radiation-Induced Oxidative Stress

Abstract

The current study examines the radioprotective properties of cinnamon-derived nanoparticles to gamma radiation. Aqueous extraction was used to synthesize cinnamon nanoparticles, and UV -Vis spectrophotometry, Atomic Force Microscopy (AFM), and Field Scanning Electron Microscopy (FSEM) were the methods used to characterize them. The morphology of the particles was quasi-spherical and the average diameter of the particles was 123.4 nm and the particles showed stability in structure. The antioxidant and free radical scavenging activity was evaluated by subjecting deionized water samples to Cs-137 gamma source in different concentrations of nanoparticles. The outcome demonstrated the dose-dependent free radical inhibition up to 60.9 percent at the concentration of 2.5 x 10^-3mg/mL. The present results highlight the potential of cinnamon nanoparticles as natural, plant-based radioprotective agents, which have a great antioxidant capacity and fundamental biological use. These properties indicate that they are promising biomedical uses especially in counteracting radiation-induced oxidative stress and the promotion of protective measures in both clinical radiotherapy and in environmental radiation exposure.